TABLE 1.
SOLAR Heritability Analysis: San Diego Caucasian Twins ChE Activity | |||||
---|---|---|---|---|---|
Trait/Covariate | H2r | H2r S.E.M. | P Value | Covariate P Value | n |
AChE | 0.4883 | 0.0610 | 9.35 × 10−11 | 364 | |
BP status | 0.4873 | 0.0609 | 8.91 × 10−11 | 0.0791 | 364 |
SBP (mm Hg) | 0.4784 | 0.0642 | 1.13 × 10−9 | 0.0193 | 343 |
ACHE SNP-13 P561R | 0.5465 | 0.0737 | 2.42 × 10−8 | 0.0126 | 274 |
ACHE SNP-16 3′-UTR | 0.6114 | 0.0638 | 1.57 × 10−10 | 0.0811 | 287 |
ACHE haplotype 1 | 0.4775 | 0.0623 | 3.31 × 10−10 | 0.0394 | 362 |
ACHE diplotype 2/4 | 0.4851 | 0.0618 | 1.68 × 10−10 | 0.0129 | 362 |
ACHE diplotype 2/7 | 0.4763 | 0.0626 | 4.08 × 10−10 | 0.0514 | 361 |
BChE | 0.814 | 0.0279 | 1.09 × 10−32 | 364 | |
Age (years) | 0.8061 | 0.0292 | 4.37 × 10−31 | 0.0031 | 364 |
Weight (kg) | 0.8015 | 0.0298 | 1.25 × 10−30 | 6.21 × 10−9 | 364 |
Height (cm) | 0.8097 | 0.0286 | 7.91 × 10−32 | 0.0278 | 364 |
SBP (mm Hg) | 0.8067 | 0.0311 | 1.63 × 10−26 | 0.0331 | 343 |
BMI (kg/mg2) | 0.7921 | 0.0312 | 1.45 × 10−29 | 4.96 × 10−12 | 364 |
BCHE SNP-1 intron-2 | 0.7822 | 0.0206 | 2.79 × 10−31 | 0.0021 | 423 |
BCHE SNP-2 3′-UTR | 0.7894 | 0.0299 | 9.1 × 10−32 | 0.0322 | 420 |
BP status, hypertensive/normotensive; ACHE SNP13, rs1799806; ACHE SNP16, rs17228616; BCHE SNP1, rs1355534 (intron-2); BCHE SNP2, rs3495 (3′-UTR); ACHE diplotype 2/4, diploid haplotype composed of ACHE haplotypes 2 and 4; ACHE diplotype 2/7, diploid haplotype composed of ACHE haplotypes 2 and 7.