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Primary hemostasis; the platelet response. Platelet aggregation at the site of injury is mediated by platelet receptors, platelet-derived agonists, platelet-derived adhesive proteins and plasma-derived adhesive proteins. Fibrin deposition around the resulting platelet plug is generated by the coagulation cascade (Figure 2). ADP = adenosine diphosphate, TXA2 = thromboxane A2 and VWF = von Willebrand factor.
