Table 1.
Interpretation and validation of the significant KEGG pathways inferred by GAGE.
| KEGG pathways | Most perturbed | References | Other evidences |
|---|---|---|---|
| TGF-beta signaling pathway | 8h | [5,57] | BMP signal targets IDs, SMAD6-7, DLX5 extremely up |
| Cytokine-cytokine receptor interaction | 8h | [33,58] | IFN target gene sets down (Table 4) |
| Wnt signaling pathway | 8h | [59,60] | |
| Jak-STAT signaling pathway | 24h | [58,61] | STAT1 target genes down |
| MAPK signaling pathway | 24h | [22,23] | -- |
| p53 signaling pathway | 24h | [62,63] | -- |
| Focal adhesion | 10d | [20,21] | -- |
| ECM-receptor interaction | 10d | [64,65] | -- |
Literature findings and experimental evidence suggest regulatory roles of these KEGG pathways in BMP6 induced osteoblast differentiation and mineralization.