Table 3.
Interpretation and validation information of the significant GO term gene sets inferred by GAGE
| GO terms | Perturbation | References | Other evidence |
|---|---|---|---|
| Notch signaling pathway | 8h-10d up | [11,25] | -- |
| insulin-like growth factor receptor binding | 8h-10d up | [26,27] | -- |
| insulin-like growth factor binding | 10d down | [28-31] | -- |
| homophilic cell adhesion | 24h-96h up | [34] | -- |
| immune response | 96h-10d down | [32,33] | -- |
| skeletal development | 8h-96h up | -- | -- |
| ossification | 96h-10d up | -- | -- |
| oxidoreductase activity | 8h-24h, 10d down | [35] | -- |
| selenium binding | 96h-10d up | -- | -- |
Temporal perturbation patterns (significantly perturbed time period and the direction), supportive literature and experimental evidence all suggest the regulatory roles of these GO terms in BMP6 induced osteoblast differentiation and mineralization.