Table 4.

Interpretation and validation information on the significant experimental sets inferred by GAGE

Experimental sets	Significant	References	Other evidences
MYB targets	8h-24h,10d down	[37,38]	Wnt signal (KEGG)
BAF57 down	8h-24h,10d down	[39-42]	BAF57 up
BAF57 up	24h-96h up	[39-42]	BAF57 down
IFNb up	8h,10d down	--	Jak-STAT signal (KEGG)
VEGF up	10d down	[43]	MYB targets
IRS down	8h-10d down	--	IGF signal (GO)

Temporal perturbation patterns, supportive literature works and extra experimental evidences all suggest the regulatory roles of these experimental sets in BMP6 induced osteoblast differentiation and mineralization. Experimental sets came from MSigDB [51] c2 collection, where the original names for these significant gene sets are: Lei_MYB_Regulated_Genes, BAF57_BT549_Dn, BAF57_BT549_Up; (B) Der_IFNB_Up, VEGF_Mmmec_6hrs_Up, IRS_Ko_Adip_Up (down regulated by IRS since up-regulated upon IRS knock down).