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. 2001 Apr 15;15(8):968–980. doi: 10.1101/gad.189601

Figure 7.

Figure 7

Model of CD44 action in logarithmic and confluent growth conditions. Specific ligands determine two functional states of CD44 that influence cytoplasmic complexes. The ligands of the growth mode have not been defined. It is, however, known that CD44, and particularly the larger-splice variants, serve as platform for the activation of growth factors (GF; Bourguignon et al. 1997; Sherman et al. 1998; Van der Voort et al. 1999; Sherman et al. 2000; V. Orian-Rousseau, L. Chen, P. Herrlich, and H. Ponta, unpubl.). (GFR) growth-factor receptor; (PP) protein phosphatase. Additional components are likely associated with the CD44-bound complexes (gray boxes).