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. 2011 Jun 29;6(6):e21193. doi: 10.1371/journal.pone.0021193

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Vasireddy et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Immunohistochemical analysis of retinal sections of curcumin treated P23H-line-1 transgenic rats with rhodopsin demonstrated the translocation of Rhodopsin protein to photoreceptor outer segment region. In control untreated retinal sections rhodopsin was found to be accumulated near the inner segment region of photoreceptors. Red indicates the labeling of rhodopsin in panels I and II and green indicates the rhodopsin labeling in panel III. Nuclei are stained with DAPI. Scale bar is 5 µM. The localization of rhodopsin is observed away from the nuclei in curcumin treated rats contrary to the localization of rhodopsin observed adjacent to the nuclei in untreated control rats thus suggesting the translocation of rhodopsin to outer segments.