Table 1. The seven microRNA-signature derived from the learning set (30 patients with schizophrenia and 30 healthy controls).
miRNA name | Chromosomal region | Location | P a value | Fold change | Expression levels in the brain |
hsa-miR-34a | 1p36.23 | Intergenic | 0.005 | 2.5 | Moderateb |
hsa-miR-449a | 5q11.2 | Intron | 0.007 | 1.9 | Lowb |
hsa-miR-564 | 3p21.31 | 3′ UTR | 0.015 | 2.4 | NA |
hsa-miR-432 | 14q32.31 | Intergenic | 0.022 | −1.4 | Highb |
hsa-miR-548d | 8q24.13 | Intron | 0.036 | 1.4 | NA |
hsa-miR-572 | 4p15.33 | Intergenic | 0.038 | 2.1 | Moderateb |
hsa-miR-652 | Xq22.3 | Intron | 0.049 | 2.4 | Moderatec |
based on the Wilcoxon rank-sum test.
miR-652 was expressed in the brain and spinal cord during embryonic stages followed by a gradual decrease after birth in a mouse model.