Table 2.
Comparison of in-vivo MRI (i) (at end-diastole) and ex-vivo (e) assessment of total heart and LV weight in WT and G7-882 mice infused for seven days with vehicle or ISO at a dose of 30 or 45 mg/kg/d
| Genotype | Drug (mg/kg/d) | BW (g) | HWe (mg) | HWe/BW, (mg/g) | LVe (mg) | LVi (mg) | LVe/BW (mg/g) | LVi/BW (mg/g) | N |
| WT | veh (30) | 30.6 ± 2.8 | 114.6 ± 9.1 | 3.8 ± 0.2 | 84.4 ± 11.2 | 87.3 ± 13.3 | 2.8 ± 0.3 | 2.8 ± 0.3 | 5 |
| ISO (30) | 29.5 ± 1.2 | 123.2 ± 9.9 | 4.2 ± 0.4 | 101.8 ± 8.1* | 100.7 ± 8.3 | 3.5 ± 0.3* | 3.4 ± 0.3* | 6 | |
| G7-882 | veh (30) | 30.8 ± 0.9 | 117.9 ± 7.5 | 3.8 ± 0.2 | 95.7 ± 6.4 | 94.2 ± 10.2 | 3.1 ± 0.2 | 3.1 ± 0.3 | 5 |
| ISO (30) | 29.8 ± 2.8 | 147.9 ± 16.5*,‡ | 5.0 ± 0.2*‡ | 119.5 ± 9.1*,‡ | 116.0 ± 9.9*,‡ | 4.0 ± 0.3*,‡ | 3.9 ± 0.4*,‡ | 6 | |
| WT | veh (45) | 34.2 ± 1.3 | 115.8 ± 10.0 | 3.4 ± 0.2 | 94.4 ± 6.9 | 92.3 ± 8.1 | 2.8 ± 0.2 | 2.7 ± 0.2 | 5 |
| ISO (45) | 30.4 ± 0.9* | 128.6 ± 9.3 | 4.2 ± 0.3* | 109.6 ± 7.8* | 106.7 ± 7.1* | 3.6 ± 0.2* | 3.5 ± 0.2* | 5 | |
| G7-882 | veh (45) | 34.8 ± 2.5 | 119.1 ± 4.3 | 3.4 ± 0.3 | 97.4 ± 4.6 | 95.3 ± 5.8 | 2.8 ± 0.2 | 2.8 ± 0.2 | 7 |
| ISO (45) | 31.0 ± 1.0* | 157.1 ± 6.2*,‡ | 5.1 ± 0.2*‡ | 132.9 ± 6.8*,‡ | 129.7 ± 11.7*,‡ | 4.3 ± 0.2*,‡ | 4.2 ± 0.4*,‡ | 9 |
Mean ± SD. HW, total heart weight; BW, body weight; LV, left ventricle weight.
*
p < 0.05, ISO vs. veh;
†
p < 0.05, WT vs. TG with veh;
‡
p < 0.05, WT vs. TG with ISO.