Table 3.
Comparison of LV end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF) and cardiac output (CO) in WT and G7-882 mice in response to vehicle or chronic (7 d) ISO stress at two doses
| Genotype | Drug (mg/kg/d) | EDV (µl) | ESV (µl) | SV (µl) | EF (%) | CO (ml/min) | n |
| WT | veh (30) | 35.8 ± 4.8 | 9.4 ± 1.8 | 26.4 ± 5.6 | 73.2 ± 6.6 | 14.1 ± 2.6 | 5 |
| ISO (30) | 53.2 ± 7.6* | 18.5 ± 7.2* | 34.7 ± 6.1* | 65.8 ± 10.8 | 19.0 ± 2.7* | 6 | |
| G7-882 | veh (30) | 37.0 ± 13.8 | 10.8 ± 4.1 | 26.2 ± 11.3 | 69.7 ± 11.4 | 13.0 ± 5.7 | 5 |
| ISO (30) | 48.5 ± 9.2 | 25.8 ± 9.1* | 22.7 ± 8.0‡ | 46.9 ± 16.8*,‡ | 12.1 ± 4.0‡ | 6 | |
| WT | veh (45) | 37.0 ± 2.2 | 11 ± 1.4 | 26.0 ± 2.1 | 70.3 ± 3.6 | 14.8 ± 1.1 | 5 |
| ISO (45) | 50.4 ± 8.2* | 25 ± 4.1* | 25.4 ± 7.0 | 49.8 ± 8.7* | 12.1 ± 3.7 | 5 | |
| G7-882 | veh (45) | 42.3 ± 7.5 | 13 ± 2.6 | 29.3 ± 5.8 | 69.1 ± 4.8 | 13.9 ± 2.4 | 7 |
| ISO (45) | 57.3 ± 6.9* | 35.6 ± 4.3*,‡ | 21.8 ± 6.1* | 37.5 ± 8.1*,‡ | 9.5 ± 3.0* | 9 |
Mean ± SD.
*
p < 0.05, ISO vs. veh;
‡
p < 0.05, WT vs. G7-882 with ISO.