Table 4.

Effect of sustained (7 d) ISO-induced stress on LV wall thickness and thickening and LV diameter in WT and transgenic G7-882 mice

Genotype	Drug (mg/kg/d)	Wall thickness			Epicardial diameter		Endocardial diameter		n
		ED (mm)	ES (mm)	Systolic thickening (mm)	ED (mm)	ES (mm)	ED (mm)	ES (mm)
WT	veh (30)	0.89 ± 0.04	1.41 ± 0.08	0.51 ± 0.09	4.94 ± 0.43	4.53 ± 0.45	2.51 ± 0.38	0.94 ± 0.22	5
	ISO (30)	1.09 ± 0.14*	1.44 ± 0.05	0.35 ± 0.14*	5.38 ± 0.53	4.96 ± 0.32	3.05 ± 0.74	1.76 ± 0.51*	6
G7-882	veh (30)	0.99 ± 0.07†	1.38 ± 0.03	0.38 ± 0.05†	5.39 ± 0.48	5.11 ± 0.42	2.59 ± 0.56	1.27 ± 0.29	5
	ISO (30)	1.22 ± 0.2*	1.47 ± 0.12	0.25 ± 0.17	5.52 ± 0.48	5.46 ± 0.41‡	3.18 ± 0.55	2.15 ± 0.61*	6
WT	veh (45)	0.91 ± 0.06	1.45 ± 0.07	0.53 ± 0.11	4.89 ± 0.4	4.8 ± 0.55	2.56 ± 0.35	1.02 ± 0.13	5
	ISO (45)	1.08 ± 0.17	1.47 ± 0.09	0.39 ± 0.17	5.12 ± 0.42	5.12 ± 0.22	3.17 ± 0.59	1.87 ± 0.53*	5
G7-882	veh (45)	0.98 ± 0.12	1.33 ± 0.13	0.35 ± 0.17	5.08 ± 0.19	4.98 ± 0.43	2.43 ± 0.62	1.30 ± 0.28	7
	ISO (45)	1.2 ± 0.12*	1.46 ± 0.11	0.32 ± 0.08	5.49 ± 0.29*	5.65 ± 0.31*,‡	3.18 ± 0.21*	2.21 ± 0.29*	9

ED, end-diastolic; ES , end-systolic. Values are mean ± SD.

^*p < 0.05 for ISO treated vs. veh groups.

^†p < 0.05 for vehicle-treated WT vs. G7-882 groups.

^‡p < 0.05 for WT vs. G7-882 groups after ISO-induced stress.