Figure 1.

Both control and E2F1 knockout mice exhibit signs of hypertrophy and fibrosis. A. Heart weight (HW, in mg) was divided by body weight (BW, in g) to determine the HW/BW ratio. #p<0.05 versus control no treatment, ˇp<0.0001 versus control no treatment. B. Myocardial sections from E2F1 +/+ and E2F1 -/- mice were stained with hematoxylin and eosin after treatment with isoproterenol. Hypertrophic changes are not significantly different between the two strains (bottom panel). Fibrosis (*) is evident in both genotypes after isoproterenol treatment but no difference is detected between the two groups. Scale bar = 50µm.