Table 1.
E2F1 +/+ | (n=6) | E2F1 -/- | (n=6) | 2-way ANOVA | |||
---|---|---|---|---|---|---|---|
Pre | Post | Pre | Post | Genotype | Drug | Interaction | |
Weight (g) | 31.1±2.9 | 32.7±2.4 | 25.6±3 | 27.3±2.4 | p<0.05 | NS | NS |
HR (bpm) | 410±60 | 538±46 | 425±33 | 506±54 | NS | p<0.05 | NS |
LA (cm) | 0.21±0.02 | 0.21±0.02 | 0.21±0.02 | 0.21±0.02 | NS | NS | NS |
MPI | 0.36±0.03 | 0.34±0.06 | 0.31±0.02 | 0.38±0.08 | NS | NS | NS |
CO (cc) | 16±4 | 26±2 | 15±2 | 26±8 | NS | p<0.05 | NS |
EDD (cm) | 0.36±0.02 | 0.38±0.03 | 0.34±0.02 | 0.32±0.03 | p<0.05 | NS | p<0.05 |
ESD (cm) | 0.21±0.03 | 0.17±0.02 | 0.17±0.02 | 0.14±0.02 | p<0.05 | p<0.05 | NS |
FS | 0.42±0.07 | 0.56±0.06 | 0.5±0.04 | 0.56±0.03 | p<0.05 | p<0.05 | NS |
E/A | 1.18±0.11 | 1.11±0.36 | 1.22±0.2 | 1.11±0.28 | NS | NS | NS |
LVMI (mg/g) | 4.6±0.5 | 6.8±1.8 | 5.2±1.3 | 6.8±1.3 | NS | p<0.05 | NS |
RWT | 0.59±0.07 | 0.69±0.08 | 0.62±0.17 | 0.88±0.17 | NS | p<0.05 | NS |
Vcf | 6.5±2.3 | 12.9±2.2 | 8.8±2 | 10.9±1.6 | NS | p<0.05 | p<0.05 |
Abbreviations: heart rate (HR), left atrial (LA), myocardial performance index (MPI), cardiac output (CO), end diastolic dimension (EDD), end systolic dimension (ESD), fractional shortening (FS), the ratio between early and late ventricular filling velocity (E/A), left ventricular mass index (LVMI), relative wall thickness (RWT), velocity of circumferential fiber shortening (Vcf).