Table 2.

Effect of angiotensin II treatment in E2F1 knockout mice. Echocardiography analysis of E2F1 +/+ wild type mice and E2F1 -/- knockout mice before and after treatment with Angiotensin II. 2-way ANOVA analysis comparing E2F1 +/+ to E2F1 -/- (genotype), pre and post drug treatment (drug) and the interaction between genotype and drug (interaction). Significance was determined when p<0.05 and is indicated not significant (NS) if value was higher than 0.05

	E2F1 +/+	(n=6)	E2F1-/-	(n=6)		2-way ANOVA
	Pre	Post	Pre	Post	Genotype	Drug	Interaction
Weight	28.1±1.4	26.8±1.8	26.8±3.1	24±3.3	NS	NS	NS
HR	360±83	442±70	469±28	488±90	p<0.05	NS	NS
LA	0.17±0.03	0.18±0.03	0.19±0.03	0.20±0.03	NS	NS	NS
MPI	0.32±0.06	0.41±0.04	0.32±0.02	0.41±0.03	NS	p<0.05	NS
CO	13±2	17±6	15±1	16±4	NS	NS	NS
EDD	0.38±0.04	0.33±0.05	0.34±0.02	0.32±0.05	NS	p<0.05	NS
ESD	0.22±0.04	0.19±0.04	0.18±0.02	0.18±0.07	NS	NS	NS
FS	0.42±0.06	0.45±0.11	0.48±0.05	0.49±0.08	NS	NS	NS
E/A	1.3±0.11	1.21±0.36	1.41±0.36	1.43±0.7	NS	NS	NS
LVMI	5±0.5	5.9±0.7	5.1±1	6.6±1.1	NS	p<0.05	NS
RWT	0.53±0.13	0.71±1	0.61±0.07	0.78±0.2	NS	p<0.05	NS
Vcf	5.9±1.8	8±3.4	9±1.7	8.6±3.2	NS	NS	NS