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. 2011 Jan 1;8(1):24–29. doi: 10.4161/rna.8.1.13618

Figure 1.

Figure 1

Interactions in the EJC cycle. The scheme shows the sequence of either simultaneous or mutually exclusive interactions underlying function of the EJC and its sub-complexes. The EJC is assembled during splicing onto the mRNA. After the mRNP is exported into the cytoplasm to function in translational regulation (ribosome in gray), the EJC is disassembled with the aid of a ribosomal-binding protein, PYM (in orange). The MAGo-Y14 heterodimer (in blue and cyan, respectively) is re-imported into the nucleus without PYM by Imp13 (in yellow). Here, it is released by RanGTP binding (gray/black rectangle) and incorporated into a spliced mRNP with eIF4AIII and BTZ (in pink and red, respectively) in the form of the EJC (other mRNP proteins are shown in gray with different shapes and sizes). mRNP composition varies dynamically as well as in the composition of the periphery of the EJC. UPF3b (in purple) associates to the EJC in the nucleus and travels with the complex to the cytoplasm. The question marks indicate open issues in the cycle: it is unclear whether eIF4AIII and BTZ are imported into the nucleus separately or as a single unit and the putative import receptor(s) has not been identified yet.