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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2011 Jul;70(7):622–633. doi: 10.1097/NEN.0b013e31822200aa

Figure 6.

Figure 6

Age-dependent changes in the cellular composition of the mouse third ventricle subventricular zone (tv-SVZ). (A, B) Representative hematoxylin and eosin-stained sections of the third ventricle in young and adult mice. (C, D) Glial fibrillary acidic protein (GFAP)-positive cells are barely detected in the third ventricle in a young mouse (C) whereas an adult mouse exhibits focal GFAP immunoreactivity with diffuse expression in ependymal cells (D). (E, F) Rare nestin-positive cells in a young mouse (E); an adult moue ependymal layer contains numerous nestin-immunopositive cells (F). Arrowheads indicate blood vessels, which serve as internal positive controls. (G, H) Acetylated tubulin immunostaining illustrates age-dependent reduction in the number of cilia. The cilia appear relatively shorter than those in the human tv-SVZ.