Table 1.

Comparison of in vivo small molecule discovery models.

	C. elegans	D. melanogaster	D. rerio	M. musculus
Generation Time	3–5 days	10–14 days	3–4 months	6–8 weeks
Media	Solid or liquid	Solid	Liquid	N/A
Ease of Obtaining Embryos	+++++	+++++	++++	N/A
Number of Genes	∼19,000	∼13,000	∼25,000	∼25,000
Homology to Human Genome	>50%	>60%	>70%	>90%
Annual Cost	+	+	++	++++