Table 3.
Overview of molecular target identification technologies.
| Strategy | Advantages | Disadvantages |
|---|---|---|
| Affinity | Traditionally used and readily accepted | Requires sophisticated equipment |
| Chromatography | Low throughput | |
| Requires chemical modification | ||
| Expression Profiling | No chemical modifications | Data can be noisy |
| High throughput | Requires sophisticated bioinformatics | |
| Imprecise | ||
| Yeast 3 Hybrid | High throughput | Non native environment |
| Not suitable for membrane bound proteins | ||
| Requires chemical modifications | ||
| DARTS | No chemical modifications | Low throughput |
| Does not require high affinity |