Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
APC represses HIF-1α. APC control of HIF-1α is indirect and requires wild-type APC, low levels of β-catenin and NFκB activity. Mutations in APC result in high levels of β-catenin, which inhibits NFκB, and hence suppresses changes in HIF-1α.
