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Direct comparison of thermophiles and mesophiles, shown as the difference in change of the thermodynamic parameter (Eq. 7) versus the difference in Tm per pairing. Points left of the Y axis signify thermophilic proteins with a smaller change in the respective thermodynamic quantity. For enthalpy, 65% of cases thermophiles have lower enthalpy than mesophiles. Similarly, the numbers are 70% for entropy and 61% for specific heat.
