Figure 2.
10J3 encodes an HMG box transcription factor. (a) Comparison of the HMG box regions of several vertebrate Sox transcription factors. 10J3 and zebrafish (z) sox17 encode members of the F subfamily. Similar types of residues are color coded. (*) Residues conserved completely in the alignment (see Materials and Methods). (b) Schematic representation of the 10J3 gene structure. The position of a conserved intron in the HMG box, the casta56 mutation and the morpholino oligonucleotide hybridization region (cas-MO) are indicated. GenBank accession no.: 10J3/cas, AY027650; mouse (m)-sox18, AAG48578, human (h)-sox18, AB033888; Xenopus (x)-sox7, D83649; mouse (m)-sox7, AB023419; putative human (h)-sox17, AK025905; mouse (m)-sox17, D49474; Xenopus (x)-sox17α, AJ001730; x-sox17β, AJ001742; and zebrafish (z)-sox17, AF168614.