Table 3.
Genes in the CCP Whose Expression was Significantly Changed by Estradiol (5 nM) or Luteolin (17.5 μM) Treatment of MCF-7 Cells for 5 Hr
| Gene | Estradiol Regulated Genes | Fold Change | Entrez Gene |
|---|---|---|---|
| CDC2a | Cell division cycle 2, G1 to S and G2 to M | 1.38 | 983 |
| CDC20a | CDC20 cell division cycle 20 homolog (S. cerevisiae) | -1.45 | 991 |
| CDC25B | Cell division cycle 25B | -1.21 | 994 |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -1.39 | 1027 |
| GSK3ba | Glycogen synthase kinase 3 beta | -1.44 | 2932 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 1.75 | 4085 |
| PCNAa | Proliferating cell nuclear antigen | 1.23 | 5111 |
| PRKDC | Protein kinase, DNA-activated, catalytic polypeptide | -1.64 | 5591 |
| Gene | Luteolin Regulated Genes | ||
| ASK | Activator of S phase kinase | 1.43 | 10926 |
| CCNA2 | Cyclin A2 | -1.45 | 890 |
| CDC2a | Cell division cycle 2, G1 to S and G2 to M | -1.27 | 983 |
| CDC20a | CDC20 cell division cycle 20 homolog | -1.5 | 991 |
| CKDN1A | Cyclin-dependent kinase inhibitor 1A (p21) | 1.67 | 1026 |
| GSK3ba | Glycogen synthase kinase 3 beta | -2.27 | 2932 |
| PCNAa | Proliferating cell nuclear antigen | -1.35 | 5111 |
| PLK1 | Polo-Like kinase 1 | -1.66 | 5347 |
| PTTG1 | Pituitary tumor-transforming 1 | -1.29 | 9232 |
a
Modulated by both Estradiol and Luteolin.