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IPTG controls LacIR repression of the TyrlacO target gene in the mouse. Mice (A), dissected eyes (B), and cross-sections through eyes (C). Note that the nontransgenic albino and the TyrlacO, LacIR double transgenic lack pigmentation, whereas the Tyrosinase transgenic and the TyrlacO, LacIR double transgenic that has been treated with IPTG are pigmented. (ONL, outer nuclear layer; RPE, retinal pigment epithelium; Scale bar represents 25 μm in C).
