Figure 5.

(A) Unbiased bioinformatics analyses also found that autophagy and lysosomal genes are most implicated in Alzheimer and Parkinson diseases, tuberous sclerosis, neuronal ceroid-lipofuscinoses, sepsis and lung, liver and prostatic neoplasms, implicating a critical role of autophagy-lysosomal pathway in these diseases. Shown are heat maps of relevance of genes and diseases. (B) A summary of the extent that knockout mice deficient of these genes exhibit nervous system phenotypes. Shown are heat maps of relevance of genes and knockout phenotypes.