Table 2.

Recommendations for the use of atazanavir/ritonavir^† with acid-suppressing agents.

	H2-receptor antagonists		Proton pump inhibitors
	Treatment-naive patients	Treatment-experienced patients	Treatment-naive patients	Treatment-experienced patients
Without tenofovir	Do not exceed dose equivalent of famotidine 40 mg twice daily‡	Do not exceed dose equivalent of famotidine 20 mg twice daily‡	Do not exceed dose equivalent of omeprazole 20 mg once daily§ Consider an increase to atazanavir/r 400/100 mg once daily	Co-administration should be avoided
With tenofovir	Do not exceed dose equivalent of famotidine 40 mg twice daily‡	Do not exceed dose equivalent of famotidine 20 mg twice daily‡ Increase atazanavir/r to 400/100 mg once daily	Do not exceed dose equivalent of omeprazole 20 mg once daily§ Consider an increase to atazanavir/r 400/100 mg once daily	Co-administration should be avoided

^†Except where noted, atazanavir should be given as 300 mg with ritonavir 100 mg once daily.

^‡Atazanavir/r should be administered simultaneously with or at least 10 h after the H₂-receptor antagonist.

^§Omeprazole should be administered approximately 12 h prior to atazanavir/r.

Atazanavir/r: Atazanavir/ritonavir.