Skip to main content
. 2011 Jul;39(7):1149–1154. doi: 10.1124/dmd.111.038349

Fig. 2.

Fig. 2.

A, structure of the bridging ELISA for detection of antibodies against the cTfRMAb-GDNF fusion protein. The cTfRMAb-GDNF fusion protein is used as the capture reagent, and the biotinylated cTfRMAb-GDNF fusion protein is used as the detector reagent, along with a complex of streptavidin (SA) and horseradish peroxidase (HRP); the biotin moiety is designated B. B, the immune response in individual fusion protein-treated mice is plotted against the number of weeks of treatment. C, the mean immune response in the mice treated with either fusion protein or saline is plotted against the number of weeks of treatment. The capture reagent in the assays shown in B and C was the cTfRMAb-GDNF fusion protein.