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. 2001 Jul 1;15(13):1631–1636. doi: 10.1101/gad.880801

Figure 5.

Figure 5

Rescue of lactation in PRLR+/− mice by deletion of a single SOCS1 allele. (A) PRLR is required by the epithelium to direct lobuloalveolar development. Mammary epithelium from PRLR+/+ and PRLR+/− mice was transplanted into cleared fourth fat pads of prepubertal Rag1−/− females, which were then taken through pregnancy. Wholemounts of 1 d postpartum mammary glands are shown. (B) Wholemount analysis of mammary glands at day 2 of lactation from SOCS1 × PRLR mice (genotype indicated). Mice were mated at 7 wk of age. Six mice of each genotype were analyzed. (C) Histological analysis of mammary glands (day 2 postpartum). Original magnification, 50×. (D) Northern analysis (10 μg of total RNA) of milk gene expression. Filters were hybridized sequentially with probes representing Keratin 19 (K19), β-casein, and WAP.