Table 4.

Multivariable logistic regression model of the associations of insulin-like growth factor (IGF)–I and IGF-binding protein (IGFBP)–3 levels with a rapid and persistent CD4⁺ T cell decline (n = 83) vs. a stable or increasing CD4⁺ T cell count (n = 190).

Variable	OR (95% CI)a	Ptrendb
Initial CD4+ T cell count stratum
50–200 cells/mm3	0.76 (0.34–1.67)
200–500 cells/mm3	0.38 (0.20–0.70)**
>500 cells/mm3	Reference
HCV seropositive	0.76 (0.34–1.67)
Age (continuous)	1.00 (0.96–1.04)
IGF-I level		.02
Fourth quartile	0.32 (0.12–0.83)*
Third quartile	0.48 (0.21–1.10)
Second quartile	0.80 (0.38–1.702)
First quartile	Reference
IGFBP-3 level		.02
Fourth quartile	2.40 (0.95–6.09)
Third quartile	2.37 (1.05–5.34)*
Second quartile	0.94 (0.42–2.09)
First quartile	Reference

NOTE. Age was parameterized as a continuous (instead of as a categorical) variable because of its fairly monotonic association with AIDS in the above analyses (see table 3) and to minimize the degrees of freedom in the current model given the smaller no. of case patients and control subjects involved in this particular analysis. CI, confidence interval; OR, odds ratio.

^a*P < .05; **P < .01; ***P < .001.

^bP_trend is reported only for ordinal data and only if statistically significant (i.e., <.05).