Substantial secretion of type 2 cytokines is only observed in subjects with high type 1 secretion. Cytokine indexes in response to CMV stimulation were grouped in type 1 (IL-2, IFN-γ and TNF-α) and type 2 (IL-4, IL-5 and IL-10), and plotted for each subject. The correlation between the sum of type 1 and type 2 cytokines was statistically significant (p ≤ 0.01) for healthy controls but not for HCV+ women (p = 0.137, panel A) as well as for HIV+ (p ≤ 0.0001) and HIV+/HCV+ women (p ≤ 0.01, panel B).