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. Author manuscript; available in PMC: 2012 Jun 28.
Published in final edited form as: Biochemistry. 2011 Jun 6;50(25):5566–5582. doi: 10.1021/bi200642e

Figure 4. The structure of the p16INK4A promoter and regulators of p16INK4A transcription.

Figure 4

Empty arrows represent the transcription directions, and plus and minus marks indicate positive and negative effects on the transcription of p16INK4A, respectively. RD: the regulatory sequence of the INK4b/ARF/INK4a locus; ITSE, the INK4a transcription silencing element; PPRE, the peroxisome proliferator response element. Sizes of the DNA elements are not in proportion strictly.