Scheme 1.
Conjugates of trimethoprim (TMP) to sensitised terbium chelate complexes. Top: cs124-polyaminocarboxylates (n=1, diethylenetriamine pentaacetic acid (TMP-cDTPA); n=2, triethylenetetraamine hexaacetic acid (TMP-cTTHA)). Bottom: Lumi4®-Tb, a proprietary 2-hydroxyisophthalamide terbium complex (TMP-Lumi4).