Table 3.
Summary of nuclear imaging results
| Prostate |
Extra-prostatic |
|||||||
|---|---|---|---|---|---|---|---|---|
| Cohort | Patient | Imaging day | GE detecteda | GEVb (cm3) | % Total | GEV:backgroundc | Total GEd | GE detected |
| 1 | 1 | 4 | N | ND | ND | ND | N | |
| 2 | 4 | N | ND | ND | ND | N | ||
| 3 | 4 | N | ND | ND | ND | N | ||
| 2 | 4 | 4 | Y | 7.8 | 17.3 | 3.3 | 25.8 | N |
| 5 | 4 | N | ND | ND | ND | N | ||
| 6 | 4 | Y | 6.6 | 26.7 | 1.5 | 9.8 | N | |
| 7 | 4 | N | ND | ND | ND | N | ||
| 8 | 2 | Y | 6.8 | 19.8 | 2.1 | 14.3 | N | |
| 9 | 2 | Y | 8.3 | 18.1 | 1.9 | 15.8 | N | |
| 10 | 2, 3, 4, 8 | Y, Y, Y, Y | 7.0 | 22.6 | 3.8 | 26.6 | N | |
| 11 | 2, 3, 4 | Y, Y, N | 1.4 | 4.3 | 1.7 | 2.4 | N | |
| 12 | 2, 3, 4, 8 | Y, Y, Y, N | 8.1 | 15.4 | 1.8 | 14.9 | N | |
| Mean | 6.6 | 17.7 | 2.3 | 15.7 | ||||
a
Gene expression (GE) detected by nuclear imaging. Y, yes; N, no.
b
Gene expression volume (GEV) detected in the prostate at maximum. The % total is the GEV divided by the total prostate volume as determined by transrectal ultrasound.
c
Ratio of mean pixel intensity in region of interest (ROI) containing gene expression to mean pixel intensity of ROI in the uninjected prostate (background).
d
Total GE is the GEV multiplied by the GEV:background ratio. The units are arbitrary.