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. 2001 Jul 1;15(13):1619–1624. doi: 10.1101/gad.900101

Figure 2.

Figure 2

Expression of a TRRAP mutant defective in HAT recruitment inhibits c-Myc oncogenic activity. (A) Primary rat embryo fibroblasts were transfected with expression vectors for c-Myc, H-RasG12V, wild-type full-length TRRAP, and the HAT-defective TRRAP(1–3760) truncation mutant in the different combinations indicated. (y axis) Number of transformed foci. Three plates were assayed for each bar. (B) TRRAP and TRRAP mutants do not inhibit colony growth. Primary rat embryo fibroblasts were transfected as indicated along with pSG5 puromycinR plasmid. PuromycinR colonies were counted after 14 d. Two plates were assayed for each bar in the graph.