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. Author manuscript; available in PMC: 2012 Jun 17.
Published in final edited form as: Org Lett. 2011 May 23;13(12):3262–3265. doi: 10.1021/ol201210t

Scheme 2.

Scheme 2

Synthesis of Omecamtiv Mecarbil and Sorafenib

aisolated yield on 1 mmol scale; average of 2 runs; isolated yield on 5 mmol scale: 78% (5a), 81% (5c). b isolated yield on 0.5 mmol scale; average of 2 runs.