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Pd-Catalyzed Cross-Coupling Reactions of Monoaryl Ureas and Aryl Halidesa
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Reaction conditions: ArCl (1.0 mmol), phenylurea (1.2 mmol), Pd(OAc)2 (1 mol %), L1 (3 mol %), Cs2CO3 (1.4 mmol), solvent (2 mL/mmol), 85 °C, 5 – 7 h; isolated yield, average of 2 runs.
2.4 mmol Cs2CO3.
3 mol % Pd, 9 mol % L1, 6 h.
3 mol % Pd, 9 mol % L1, 60 °C, 5 h.
6 mol % Pd, 18 mol % L1, 75 °C, 8 h, and the ArBr was used as the substrate.
