Table 4.

Cox proportional Hazard model for prediction of all-cause mortality by tertile of IL-6 stratified for gender among N = 370 subjects of the MEMO study

N = 370		Female (N = 173)			Male (N = 197)
Cytokine (pg/ml) tertile		Death/N	Death/per 100 person years	HR, 95% CI; p value	Death/N	Death/per 100 person years	HR, 95% CI; p value
IL-6	Lower (<0.68)	16/66	3.73	Ref.	13/67	2.99	Ref.
	Middle (0.68–2.19)	7/62	1.74	0.47, 0.2–1.2; 0.10	18/52	5.33	1.74, 0.8–3.6, 0.13
	Upper (>2.19)	14/45	4.79	1.13, 0.5–2.4; 0.74	42/78	8.30	2.47, 1.3–4.7; 0.006
IL-8	Lower (<5.58)	13/68	2.95	Ref.	17/56	4.68	Ref.
	Middle (5.58–8.39)	9/57	2.43	0.67, 0.3–1.6; 0.38	23/69	5.13	1.05, 0.6–1.9; 0.89
	Upper (>8.39)	15/48	4.82	1.63, 0.7–3.6; 0.23	32/72	6.85	1.35, 0.7–2.5; 0.34
IL-10	Lower (<1.41)	14/78	2.77	Ref.	23/69	5.13	Ref.
	Middle (1.41–2.97)	10/42	3.67	1.283, 0.6–3.0; 0.562	20/58	5.31	1.14; 0.6–2.1; 0.68
	Upper (>2.97)	13/53	3.78	1.43, 0.7–3.1; 0.37	30/70	6.60	1.24, 0.7–2.1; 0.45

Fifteen individuals of N = 385 were excluded from the analyses due to missing data; HR model = IL-6/IL-8/IL-10 tertile plus covariates age, smoking, vascular, and bone morbidity

HR hazard ratio; 95% CI 95% confidence interval