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. 2001 Aug 1;15(15):1913–1925. doi: 10.1101/gad.903001

Figure 7.

Figure 7

Role of Ink4a–Arf loss, p53 loss in PDGF-induced gliomagenesis from Gtv-a mice. (A) Ink4a–Arf loss, but not p53 loss, resulted in a shortened tumor latency and an increased total tumor incidence (70% vs. 39%); (B) Ink4a–Arf loss also significantly enhanced the malignancy of gliomas induced from Gtv-a mice. In summary, the most malignant gliomas arose from the combination of both neural progenitor cell of origin and loss of Ink4a–Arf. (O) Oligodendroglioma (WHO classification); (AO) anaplastic oligodendroglioma (WHO classification). Final tumor incidence for each genetic background is indicated by the arrows.