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. 2011 Jul;80(1):174–182. doi: 10.1124/mol.110.070896

Fig. 7.

Fig. 7.

Repeated injections of LY379268 (0.5 mg/kg i.p., twice a day, 3 consecutive days) decrease the number of methylated cytosines in reelin, GAD67, and BDNF-IX CpG-rich promoter regions. The study compared saline-injected animals (open bar, control) with mice pretreated with Met (750 mg/kg s.c., twice a day, 7 consecutive days) (closed bars). Reelin, GAD67, and BDNF-IX promoter methylation was measured 24 h after Met treatment termination and the last injection of LY379268. Values are the ratios between the amount of the gene promoter fragment immunoprecipitated by 5-methylcytosine antibodies and the promoter fragment present in the initial total extract (input) (percentage of total). Values represent the mean ± S.E. of five mice. *, p < 0.05, versus control group; #, p < 0.01 versus Met-treated mice receiving saline instead of LY379268 (one-way ANOVA + Newman-Keuls).