Fig. 5.

Determination of ALT activities in serum of PXR wild-type mice after PCN, APAP, and FLB-12 (Cpd3) combinatorial treatment groups. PXR wild-type mice (n = 8/groups) were pretreated with corn oil (vehicle) or FLB-12 on day −1 before PCN dosing and continued through acetaminophen dosing for a total of 4 days. Blood was collected and serum was separated as described under Materials and Methods. ALT levels were measured according to the manufacturer's instructions. Columns, bars, S.E.M. *, P < 0.05; **, P < 0.05.