Fig. 6.

hERG tail current density averages obtained by measuring the hERG tail peak amplitude at −7 mV in baseline conditions and in the presence of 5, 10, 20, and 50 μM ketoconazole (Table 2) or FLB-12 (Cpd3; Table 3). A, representative recordings of activating and inactivating hERG currents in baseline conditions and after exposure of the cells to 50 μM ketoconazole or 50 μM FLB-12. B, current density was measured from seven cells, averaged, normalized against baseline current density, and corrected for time and solvent effects. KTZ IC₅₀ is 18 μM; FLB-12 IC₅₀, not available. Statistical comparisons between current density levels after drug exposure and at baseline were made using repeat paired Student's t tests: differences were considered significant at P ≤ 0.05.