TABLE 1.

FLB-12 concentrations in mouse and human tumor xenograft tissues

Six- to eight-week-old C57BL/6 female and SCID/NOD mice xenografted with LS174T cells (group average flank tumor volume ∼0.45 mm³) were injected with rifampicin (50 mg · kg⁻¹ · day⁻¹ i.p.) and/or orally gavaged FLB-12 (300 mg · kg⁻¹ · day⁻¹) for 4 days. All tissues were harvested on day 4 for assessment of FLB-12 concentrations, as described under Materials and Methods.

Samples & Treatment Groups	Concentration
	μM
Plasma
FLB-12	28.0 ± 3.5
Rifampicin/FLB-12	33.31 ± 1.69
Liver
FLB-12	23.45 ± 1.55
Rifampicin/FLB-12	23.1 ± 4.4
Tumor (LS174T xenografts)
FLB-12	24.5 ± 2.1
Rifampicin/FLB-12	23.475 ± 3.325