Fig. 4.

Transport of [³H]pentamidine in wild-type and ABR cell line lines. Transport of 30 nM (A and B) or 1 μM [³H]pentamidine (C and D) was assessed in bloodstream forms of the s427WT (A and C) and ABR (B and D) cell lines over 60 s in the presence or absence of various concentrations of propamidine (■) or unlabeled pentamidine (○). Pentamidine uptake was expressed as picomoles per 10⁷ cells per second. The experiments were performed in triplicate; error bars represent S.E. of internal replicates. Data shown are representative of at least three identical and independent experiments.