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Effects of the mutations on BZD maximal potentiation. Representative current traces showing maximal potentiation of GABA EC15 current from oocytes expressing WT and mutant receptors by FZM (A), ESZ (B), or ZPM (C). In all cases, BZDs were at concentrations that elicited maximal responses. I bar in A indicates potentiation of IGABA. Note: in B, for αF99Cβγ receptors, ESZ inhibited IGABA.
