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Mutations throughout the BZD binding site affect BZD efficacy. Maximal potentiation of GABA EC15 current from WT and mutant receptors by FZM (A), ESZ (B), or ZPM (C) is plotted. BZD potentiation was calculated as [(IGABA+BZD/IGABA) − 1]. Data are mean ± S.E.M. from at least three oocytes from two or more batches. Dashed lines indicate WT levels of potentiation. Black bars indicate values that are significantly different from WT (*, p < 0.05; **, p < 0.01).
