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. Author manuscript; available in PMC: 2011 Jun 30.
Published in final edited form as: J Immunol. 2011 Feb 14;186(6):3472–3483. doi: 10.4049/jimmunol.1003299

Figure 5.

Figure 5

Manipulations in the rate constants for TNFR1 internalization (kint1) and mTNF synthesis (ksynthMac) lead to different effects on model outputs. Simulation results show the effect of manipulations in kint1 and ksynthMac on (A) bacterial levels 200 days after Mtb infection, (B) maximum sTNF concentration, (C) maximum fraction of macrophages that become activated following Mtb infection and (D) TNF-induced macrophage apoptosis within a 200-day period after Mtb infection (No internalization: kint1 = 0, rapid TNF synthesis: ksynthMac = 1 #/cell.s, rapid internalization: kint1 = 1.5×10−3 s−1, slow TNF synthesis: ksynthMac = 0.1 #/cell.s).