Table 4.
A. nidulans wild-type, cclAΔ, cclAΔ mdpGΔ, and alcA(p)::mdpE strains exhibit similar patterns of susceptibility to 2-OHa
| 2-OH treatment (μM) | Growth of strain in RPMI with indicated 2-OH concn |
Growth of alcA::mdpE in RPMI + 30 mM cyclopentanone | |||
|---|---|---|---|---|---|
| WT | cclAΔ | cclAΔ mdpGΔ | alcA::mdpE | ||
| 567 | − | − | − | − | − |
| 284 | − | − | − | − | − |
| 142 | + | − | + | − | − |
| 71 | + | + | + | + | + |
| 35 | + | + | + | + | + |
| 18 | + | + | + | + | + |
| 9 | + | + | + | + | + |
| Untreated control | + | + | + | + | + |
a
The patterns of susceptibility suggest that the monodictyophenone gene cluster does not include a resistance-encoding gene to protect the fungus from the metabolites produced by this pathway. The symbols + and − denote growth and no growth, respectively. Growth was assessed by microscopic visualization of wells 48 h post treatment.