Table 1.

Amino acid substitutions in HUα

Position	Native amino acid	Substituted amino acid
4	threonine	alanine
5	glutamine	aspartate
8	aspartate	serine
12	glutamate	phenylalanine
17	serine	proline
18	lysine	alanine
19	threonine	aspartate
22	lysine	glycine
30	alanine	glutamate
38	glutamate	lysine

The substituted amino acids were chosen from amino acids at the corresponding positions in HU from other species (see text).