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. 2001 Sep 1;15(17):2209–2214. doi: 10.1101/gad.205701

Figure 1.

Figure 1

The mouse HoxD cluster, the human PAC, and nested deletions. (A) The HoxD complex (top) with genes as black boxes (red for human). Below is the human PAC 78j1, with the human HOXD3 to EVX2 genes and 30 kb of DNA upstream, and the mouse BAC 400h17, with the murine cluster and 100 kb of DNA upstream. (B) Scheme of nested deletions. (Top) The HoxD complex with a Hoxd11/lacZ reporter transgene inserted upstream of Hoxd13. After recombination of a loxP site within Hoxd1 (arrowhead), Cre-mediated deletion removed the cluster leaving the reporter gene construct TgHd11/lacDel9 (below). The bottom lines are intermediate configurations obtained by using other loxP sites within the cluster. After recombination, partial deletions of either three (Del3) or seven (Del7) genes are obtained, with the reporter transgene at the same position.