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Vertebral and limb phenotypes. (Top) Skeletal preparations of lumbo–sacral transitions. Wild-type mice have six lumbar vertebrae (L6). Mice transgenic for human HOXD PAC (TgN[HOXD]) had an anteriorized lumbo–sacral transition with L5. In contrast, mice carrying a deletion of Hoxd13 to Hoxd11 showed seven lumbar vertebra (L7). When the human HOXD transgene was added to this latter configuration (TgN[HOXD]; Del3/Del3), the L7 phenotype was rescued to L6.
