Table 2.
Tumor spectrum of RIZ1 and p53 doubly mutant mice
| Tumors
|
RIZ1−/−p53+/−
|
RIZ1+/−p53+/−
|
RIZ1+/+p53+/−
|
|---|---|---|---|
| DLBL | 9 (69%) | 1 (12.5%) | 0 |
| sarcoma | 1 (8%) | 5 (62.5%) | 2 (50%) |
| thymus lymphoma | 2 (16%) | 1 (12.5%) | 1 (25%) |
| squamous cell carcinoma | 0 | 1 (12.5%) | 0 |
| lung adenocarcinoma | 1 (8%) | 0 | 0 |
| testis tumor | 0 | 0 | 1 (25%) |
| Total | 13 | 8 | 4 |
Tumors were found in moribund or dead animals in a cohort of 34 RIZ1−/−p53+/−, 32 RIZ1+/−p53+/−, and 40 RIZ1+/+p53+/− animals. Numbers in parentheses indicate the percentage of the total number of tumor incidences.